About the Position

The School of Mathematics and Statistics at the University of St Andrews invites applications for a fully funded PhD project titled "Decomposing Optic Cup Formation Using a Morpho-Elastic Computational Model." This interdisciplinary project, supervised by Dr. Jochen Kursawe (St Andrews) and Dr. Joe Rainger (University of Edinburgh), offers an exceptional opportunity to combine applied mathematics, computational modelling, and developmental biology to advance our understanding of eye morphogenesis.

This PhD position is part of the EASTBIO Doctoral Training Partnership, offering access to world-class training and a vibrant research community.

Project Overview

The development of the optic cup—a critical process in early eye formation—requires the precise coordination of cellular behaviors, including:

• Cell shape changes: Pulsatile constrictions on the basal side.
• Cell movements: Rim cells transitioning to the inner layer.
• Differential tissue tension: Influencing the invagination process.
• Spatial constraints: Leading to tissue buckling and morphogenesis.

Disruptions in these processes result in serious developmental eye disorders such as Microphthalmia, Anophthalmia, and Coloboma, which collectively affect up to 25% of childhood blindness cases.

This PhD project will develop a finite-element morpho-elastic computational model to simulate and analyze these processes, focusing on both optic cup invagination and fissure closure. The model will be validated against existing quantitative data on cell behavior, geometry, and signaling, enabling predictions on which mechanisms most influence morphogenesis. Findings will directly inform experimental approaches in collaboration with researchers at the Universities of Edinburgh and Manchester using zebrafish and chick models.

Key Responsibilities

As a PhD candidate, you will:

• Develop a finite-element morpho-elastic computational model to simulate optic cup morphogenesis.
• Analyze the relative contributions of cell shape changes, movements, differential tension, and spatial constraints.
• Validate the model using published data on cell behavior, geometry, and signaling.
• Collaborate with experimental teams to test model predictions in biological systems.
• Present findings at national and international conferences.
• Publish research outcomes in high-impact peer-reviewed journals.

Eligibility Requirements

We are looking for a motivated candidate with the following qualifications:

1. Academic Background:
   • Master’s or strong Bachelor’s degree in Applied Mathematics, Computational Biology, Developmental Biology, or a related field.
2. Skills and Experience:
   • Experience in computational modeling, ideally using finite-element or morpho-elastic frameworks.
   • Strong programming skills in relevant languages (e.g., Python, MATLAB, or similar).
   • An understanding of developmental biology or a willingness to learn.
   • Excellent analytical and problem-solving skills.
3. Personal Attributes:
   • Ability to work independently and as part of a multidisciplinary team.
   • Strong communication skills for presenting complex concepts to diverse audiences.
   • A proactive approach to learning and research challenges.
4. Language Requirements:
   • Applicants whose first language is not English must meet the university’s language proficiency requirements.

What We Offer

• Funding: A fully funded PhD scholarship covering tuition fees and a stipend for living expenses.
• Training and Development: Access to EASTBIO Doctoral Training Partnership workshops, courses, and professional development opportunities.
• Collaborative Environment: Work within a multidisciplinary team of mathematicians, biologists, and computational scientists.
• Resources: State-of-the-art computational facilities and support.
• Research Impact: Contribute to advancing knowledge in eye development and childhood blindness.

Application Process

To apply for this position, follow these steps:

1. Visit the EASTBIO website and download the required forms.
   • Equality, Diversity, and Inclusion survey
   • EASTBIO Application Form
2. Complete your online application to St Andrews University via the Online Application Portal.

Your application must include:

• Completed EASTBIO application form.
• Two references (submitted on the EASTBIO Reference Form).
• Academic qualifications (transcripts and certificates).
• English language qualification (if applicable).

Important: Incomplete applications cannot be considered. Ensure all required documents are submitted by January 17, 2025.