Overview

The University of Bath invites applications for a PhD position focusing on the development of automated workflows for elucidating catalytic reaction mechanisms. This cutting-edge project integrates advanced reaction monitoring techniques and data analysis methods, offering a transformative approach to understanding catalytic processes essential to pharmaceutical and fine chemical production.

This project is in collaboration with AstraZeneca and the Institute of Sustainability and Climate Change, ensuring industrial relevance and access to additional training and placement opportunities. The successful candidate will join a vibrant research environment with access to the £1.3m Dynamic Reaction Monitoring (DReaM) Facility and its state-of-the-art analytical tools.

Project Highlights

The research aims to develop an automated process for analyzing catalytic reaction mechanisms using a combination of real-time reaction monitoring techniques such as:

• Multi-nuclear high-resolution FlowNMR
• UV-vis spectroscopy
• IR/Raman spectroscopy

The project will involve:

• Collecting and analyzing reaction progress data and catalyst distribution profiles.
• Utilizing modern reaction kinetics methods like RPKA and VTNA with automated analysis.
• Developing algorithms to deduce reaction mechanisms and explore global reaction kinetics.
• Addressing deactivation phenomena with minimal experiments through controlled parameter modulation.

The outcomes will significantly advance mechanistic understanding and provide actionable insights for optimizing catalytic processes.

Eligibility Requirements

Applicants should hold or expect to receive:

• A First-Class or high Upper Second-Class UK Honours degree (or equivalent) in Chemistry or a related field.
• A Master’s degree in a relevant subject is advantageous.
• A solid understanding of physical chemistry and homogeneous catalysis.

Additionally, candidates should demonstrate:

• An intrinsic interest in reaction mechanisms and an aptitude for learning advanced analytical techniques.
• A methodical approach to research with attention to detail.
• Strong motivation and the ability to work collaboratively and independently.

Responsibilities

• Conduct cutting-edge research using advanced reaction monitoring techniques.
• Develop and validate automated workflows for mechanistic analysis.
• Collaborate with AstraZeneca to address real-world catalytic challenges.
• Disseminate findings through publications and conferences.
• Participate in training, outreach, and academic activities within the Department of Chemistry.

What We Offer

• Funding: A fully-funded 3.5-year studentship, covering tuition fees, a stipend of £19,237 (2024/25), and a training support budget.
• Training and Facilities: Access to the world-class DReaM Facility and professional development resources.
• Collaboration: Work closely with AstraZeneca, benefiting from industrial placements and co-supervision.
• Supportive Environment: Join an inclusive and diverse research community committed to academic excellence and innovation.

Application Process

Interested candidates should submit their formal application via the University of Bath’s online application portal before the deadline.

Important Application Instructions:

1. In the "Funding your studies" section, select "University of Bath URSA."
2. Quote the project title and lead supervisor (Dr. Ulrich Hintermair) in the "Your PhD project" section.

Applications must include:

• A detailed CV.
• Academic qualifications and transcripts.
• A personal statement outlining research interests and motivation for applying.
• Two references.
• Evidence of English language proficiency (if applicable).

Application Deadline: February 17, 2025. Applications may close earlier if a suitable candidate is found.

Contact Information
For informal inquiries, please contact Dr. Ulrich Hintermair.