About the Research

This cutting-edge research opportunity combines computational modeling and experimental validation to address the fundamental molecular mechanisms of membrane fusion and its potential applications in drug delivery and vaccination. Membrane fusion is a vital biological process with roles in neurotransmission, immune responses, and intracellular trafficking. 

This project seeks to design novel peptides and peptide aggregates capable of inducing spontaneous membrane fusion. Using computational approaches, we aim to identify critical peptide properties to manipulate key fusion states, including the membrane stalk, hemifusion diaphragm, and fusion pore. The computational predictions will be validated through fluorescence and electron microscopy techniques, offering a comprehensive approach to peptide design.

Key Responsibilities

• Develop computational methods to identify properties of peptides influencing membrane fusion.
• Conduct de novo peptide design to manipulate fusion processes.
• Validate computational predictions through experimental methods, such as fluorescence microscopy and electron microscopy.
• Collaborate with team members and contribute to ongoing projects within the research group.
• Present findings in scientific publications and at international conferences.

Eligibility Requirements

Must-have:

• MSc or equivalent degree in computational simulations or related fields.
• Strong theoretical understanding of Molecular Dynamics and/or Monte Carlo methods.
• Proficiency in spoken and written English.

Nice-to-have:

• Experience with protein or membrane simulations and their analysis.
• Strong interpersonal and communication skills.
• Motivation and a collaborative mindset.

What We Offer

• State-of-the-art facilities: Access to CEITEC MU core facilities and cutting-edge equipment.
• Attractive salary: Competitive compensation funded by an ERC grant.
• Contract type: Full-time position.
• Flexible working hours.
• Benefits package, including:
  • 6 weeks of paid holidays.
  • Medical insurance.
  • Financial contributions for meals, kindergartens, and pensions.
  • Multisport card for fitness and wellness.
  • On-campus mental health care and sports lessons.
  • Access to Elánek Kindergarten on campus.
• Professional development: Opportunities for further education, participation in workshops, conferences, and training events.
• Support services:
  • Assistance with relocation via the Welcome Office.
  • Support from the Grant Office.
  • Networking opportunities through CEITEC events and the Postdoc Peer Committee.

How to Apply

Application Deadline: December 31, 2024

Start Date: January 1, 2025, or as negotiated.

To apply, submit the following documents via the e-application portal:

1. A CV detailing your academic and research experience.
2. A motivation letter explaining your interest in the position.
3. A list of publications.
4. Contact information for two references.