About the Position

This exciting role is part of a Karolinska Institutet KID grant and the European Network Infraplus project. The research is guided by the 3R principles (Reduce, Refine, Replace) to enhance in vitro modeling techniques, aiming to minimize reliance on animal testing while advancing understanding of bacterial translocation mechanisms across the blood-brain barrier.

You will work with Team Herland and Team Melican at AIMES, an interdisciplinary research center co-affiliated with Karolinska Institutet (KI) and KTH Royal Institute of Technology (KTH). AIMES is a hub for cutting-edge biomedical research, focusing on infection and neuroscience through innovative technologies such as Organ-on-Chip and Tissue Microbiology.

Your Responsibilities

• Develop microfluidic blood-brain barrier models using mouse neurovascular cells and human-derived cells.
• Validate in vitro models by correlating them directly with in vivo mouse data.
• Apply advanced models to study bacterial translocation mechanisms causing bacterial meningitis.
• Conduct primary and stem cell handling, differentiation, and microfluidic integration.
• Employ microbiology approaches, molecular assays, and in vivo techniques.
• Optimize and innovate methodologies to address complex research questions.

Eligibility Requirements

To qualify for this PhD position, you must meet the following requirements:

General Eligibility:

• A Master’s degree in Biomedicine, Molecular Biology, or equivalent.
• Completion of at least 240 higher education credits, including 60 second-cycle (Master’s) credits.

Specific Eligibility:

• Proficiency in English equivalent to English B/6 at Swedish upper secondary school.
• Relevant documentation verifying general and specific eligibility.

Desirable Skills:

• Advanced experience in cell biology (primary and stem cells).
• Familiarity with BSL2 safety levels and microfluidic models.
• Training in microbiology and skills in microscopy, molecular biology, or related assays.
• Strong interpersonal and communication skills in English (written and oral).

What We Offer

Karolinska Institutet provides an inspiring environment for medical research, emphasizing creativity, collaboration, and global impact. As a PhD student, you will receive:

• A full-time doctoral studentship with a contractual salary.
• Access to a world-class research network and opportunities for international exchange.
• Comprehensive support for professional development, elective courses, and supervisor guidance.
• Additional benefits, including free gym access and medical care reimbursements.

Application Process

Submit your application via the Varbi recruitment system by January 3, 2025. Ensure your application includes the following:

1. Personal letter and curriculum vitae (CV).
2. Documentation of degree projects and prior publications (if applicable).
3. Proof of eligibility (general and specific).
4. Other documents showcasing your skills and personal qualities relevant to the role.

Applications will be assessed based on subject knowledge, analytical skills, and documented experience relevant to the project.

For more details, visit Karolinska Institutet’s AIMES website.

Join us at Karolinska Institutet and contribute to world-class research transforming healthcare. Apply today!