About the Project

• Primary Supervisor: Dr. rer. nat. Fraser MacMillan
• Industry Partner: Nanotemper Technologies GmbH (CASE Partner)

This project will investigate the architecture, dynamics, and function of membrane proteins, particularly focusing on the SLC6 sodium symport transporter (LeuT). LeuT is structurally similar to human neurotransmitter transporters for dopamine, serotonin, norepinephrine, and gamma-aminobutyric acid (GABA), which are involved in critical neurological processes.

Research Focus:

1. Membrane Transport Proteins and Neurotransmitter Systems:

   • Examine the structural and functional similarities between LeuT and human neurotransmitter transporters.
   • Study their roles in neurological disorders such as depression, ADHD, and anxiety.
   • Explore interactions between transporters and prescribed medications (e.g., antidepressants) and illicit drugs (e.g., cocaine and amphetamine).

2. High-Value Pharmaceutical Targets:

   • Investigate additional proteins such as Cereblon and Von Hippel-Lindau (VHL).
   • These proteins are significant in drug development and the study of complex disease mechanisms, including cancer.

3. Development of Novel Probes and Labeling Methods:

   • Create innovative labeling approaches that are scalable for high-throughput experiments.
   • Apply advanced biophysical techniques such as fluorescence, magnetic resonance, and NMR to monitor protein function.

This multidisciplinary research will provide new insights into how nano-scale protein machines operate with high precision and coordination, advancing our understanding of their roles in health and disease.

Training and Professional Development

This studentship offers world-class training that will empower you with advanced skills in biophysics, molecular biology, and chemistry. You will:

• Gain hands-on experience with state-of-the-art equipment for biophysical, biochemical, and molecular biology research.
• Receive tailored mentorship and training in fluorescence, magnetic resonance, and NMR spectroscopy.
• Work within a collaborative, team-oriented environment at UEA, part of the vibrant Norwich Research Park (NRP) community.
• Undertake a 3–18 month placement with Nanotemper Technologies GmbH, where you will apply your research in a real-world industry setting.

The programme also offers comprehensive professional development support, preparing you for diverse career paths in academia, pharmaceuticals, or industry. Dedicated advisors from UEA’s Professional Internship team will assist you throughout the placement process.

Why Apply?

• Cutting-Edge Research:
  Contribute to the development of next-generation pharmaceuticals by advancing our understanding of protein transport systems and their interaction with drugs.
• International Collaboration:
  Engage in a global partnership between UEA and Nanotemper Technologies GmbH, gaining invaluable industry experience.
• Top-Tier Facilities:
  Access the world-class research infrastructure at the Norwich Research Park and UEA.

Eligibility Criteria

• Academic Requirements:

  • A Bachelor’s degree with at least 2:1 honours or equivalent qualification.
  • Alternatively, a Master’s degree in a relevant subject area (Chemistry, Pharmacy, Biophysics, or related fields).

• English Language Proficiency:

  • IELTS score of 6.5 overall with 6.0 in each category (or equivalent qualification).

Funding and Financial Support

This PhD studentship is fully funded as part of the Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) CASE programme:

• Tuition Fees: Paid directly to the University of East Anglia.
• Annual Stipend: £19,237 per year (2024/25 rate) to support living expenses.
• Research Training Support Grant: £5,000 per year for research-related costs.

Important Dates and Application Process

• Application Deadline: 25 November 2024
• Interviews: Shortlisted candidates will be interviewed on 28, 29, or 30 January 2025.

Interested applicants should visit the NRPDTP website for more information on eligibility and how to apply.

Why Norwich?

According to the Sunday Times, Norwich is among the best places to live in the UK, offering a friendly community and vibrant cultural scene. As part of the Norwich Research Park, you’ll join a dynamic group of world-class scientists and researchers working on cutting-edge projects with global impact.

UEA and its partners are committed to promoting a diverse and inclusive work environment, welcoming candidates of all genders, ethnic backgrounds, and social identities. Selections are made without discrimination based on gender, disability, nationality, or religion.

Recent Publications from the MacMillan Lab

• Tsalagradas P., Eke C., Andrews C., & MacMillan F. (2024). Exploring the structural dynamics of LeuT using EPR spectroscopy: A focus on transmembrane helix 10. (In revision for Journal of Neurochemistry).
• Barber-Zucker S. et al. (2020). The cation diffusion facilitator protein MamM exhibits metal-type dependent binding modes. Journal of Biological Chemistry, 295(16614–16629).
• Hall J. et al. (2020). Saturation transfer difference NMR on the integral membrane protein GltPh determines cooperative substrate binding. Scientific Reports, 10(16483).

How to Apply

Take the next step in your academic and professional journey by applying for this exciting PhD opportunity. Apply here